No DAC — GHRH Analogue
5mg / vial
CJC-1295 without DAC (also known as Modified GRF 1-29) is a shortened, stabilised analogue of growth hormone releasing hormone (GHRH). It is the most widely used GHRH analogue in research settings — commonly paired with Ipamorelin to investigate pulsatile growth hormone release.
The 'No DAC' designation refers to the absence of the Drug Affinity Complex — a modification that would extend the peptide's half-life significantly. Without DAC, CJC-1295 has a short active window (approximately 30 minutes) that more closely mimics the natural pulsatile pattern of GHRH secretion.
CJC-1295 (No DAC) binds to GHRH receptors on the anterior pituitary and stimulates the release of growth hormone in a pulse. Research pairing it with a GHRP such as Ipamorelin has shown synergistic amplification of GH output, making it the canonical combination for GH axis research protocols.
Research has investigated GHRH analogues in contexts including body composition, bone density, sleep quality, and metabolic regulation. CJC-1295 No DAC is preferred when pulsatile, physiological-pattern GH release is the research objective.
Commonly researched with