Nicotinamide Adenine Dinucleotide
100mg / vial
NAD+ (Nicotinamide Adenine Dinucleotide) is an essential coenzyme present in every living cell. It plays a central role in cellular energy production, DNA repair, and the regulation of hundreds of metabolic processes. NAD+ levels decline significantly with age — a finding that has driven substantial research interest in supplementation and restoration strategies.
NAD+ is a dinucleotide coenzyme consisting of two nucleotides joined through phosphate groups. It functions as a critical electron carrier in mitochondrial oxidative phosphorylation, and as a substrate for sirtuins (SIRT1-7), PARP enzymes involved in DNA repair, and CD38 — an enzyme whose activity rises with age and contributes to NAD+ decline.
As a sirtuin substrate, NAD+ activates SIRT1 and SIRT3, which regulate mitochondrial biogenesis, inflammation, and cellular stress responses. Research has shown that restoring NAD+ levels in aged cell and animal models reverses markers of cellular ageing, improves mitochondrial function, and enhances DNA repair capacity.
NAD+ research spans mitochondrial biology, ageing and longevity science, neurodegeneration, cardiovascular health, and metabolic disease. Studies have been conducted at institutions including Harvard, the Salk Institute, and the National Institutes of Health.
Commonly researched with